What is the duration of action of an ephedrine IV bolus?

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Study for the Vasopressors and Inotropes Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Multiple Choice

What is the duration of action of an ephedrine IV bolus?

Explanation:
Ephedrine IV bolus produces a rapid, transient rise in blood pressure and heart rate because it works through mixed direct and indirect adrenergic actions, including release of endogenous norepinephrine. The pressor and chronotropic effects appear quickly, but they don’t last long because the drug redistributes quickly from the central circulation into peripheral tissues and is metabolized and cleared fairly rapidly. This redistribution and clearance keep the duration of action in the short range, typically about 3 to 10 minutes. If a longer effect is needed, the dosing is repeated or an infusion is used.

Ephedrine IV bolus produces a rapid, transient rise in blood pressure and heart rate because it works through mixed direct and indirect adrenergic actions, including release of endogenous norepinephrine. The pressor and chronotropic effects appear quickly, but they don’t last long because the drug redistributes quickly from the central circulation into peripheral tissues and is metabolized and cleared fairly rapidly. This redistribution and clearance keep the duration of action in the short range, typically about 3 to 10 minutes. If a longer effect is needed, the dosing is repeated or an infusion is used.

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